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Image Search Results
Journal: Experimental and Therapeutic Medicine
Article Title: Purpurogallin carboxylic acid exhibits synergistic effects with 5‑fluorouracil on liver cancer cells in vitro by targeting ABCG2
doi: 10.3892/etm.2024.12564
Figure Lengend Snippet: PCA combined with 5-FU induces the G1 phase cell cycle arrest in liver cancer cells. (A) Flow cytometry was carried out to evaluate the cell cycle distribution in HepG2, Huh7 and Huh1 cells treated with DMSO, 10 µM PCA, 10 µM 5-FU or their combination. Western blot analysis was performed to detect the protein expression levels of CDK4 and CDK6 in (B) HepG2, (C) Huh7 and (D) Huh1 cells treated with DMSO, 10 µM PCA, 10 µM 5-FU or their combination. Reverse transcription- quantitative PCR was performed to detect the mRNA levels of CDK4 and CDK6 in (E) HepG2, (F) Huh7 and (G) Huh1 cells treated with DMSO, 10 µM PCA, 10 µM 5-FU or their combination. * P<0.05 and ** P<0.01. PCA, purpurogallin carboxylic acid; 5-FU, 5-fluorouracil; CDK, cyclin-dependent kinase.
Article Snippet: Following blocking with 8% skim milk powder in TBS-Tween-20 (0.1%) (TBST) for 2 h at 28 ̊C, the membranes were incubated with primary
Techniques: Flow Cytometry, Western Blot, Expressing, Reverse Transcription, Real-time Polymerase Chain Reaction
Journal: Heliyon
Article Title: MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
doi: 10.1016/j.heliyon.2024.e28172
Figure Lengend Snippet: Box plots of MTCH2 expression levels and Kaplan-Meier curves for OS: (A) GSE7377, (B) GSE54002, (C) GSE45827, (D) TCGA-BRCA, (E) GSE26459; (F) TCGA-BRCA, (G) microarray data of BC patients, (H) the luminal A subtype, (I) the luminal B subtype, (J) the Her2 + subtype, and (K) the basal subtype. Abbreviations: OS, overall survival.
Article Snippet: The following antibodies were used:
Techniques: Expressing, Microarray
Journal: Heliyon
Article Title: MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
doi: 10.1016/j.heliyon.2024.e28172
Figure Lengend Snippet: MTCH2 expression was upregulated in BC cell lines: (A) qPCR, (B) Western blot and (C) quantitation of Western blot band intensities; It was successfully suppressed and activated by corresponding lentiviral systems: (C) qPCR, (D) Western blot and (F) quantitation of Western blot band intensities.
Article Snippet: The following antibodies were used:
Techniques: Expressing, Western Blot, Quantitation Assay
Journal: Heliyon
Article Title: MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
doi: 10.1016/j.heliyon.2024.e28172
Figure Lengend Snippet: MTCH2 promotes cellular growth and cycle progression. CCK-8 assay revealed increased cell viability in MTCH2 overexpressing cell lines (A), and suppressed in silenced cells (B); The represented graph of cell cycle analysis by PI staining and flow cytometry (C–E), transition was arrested in silenced cells (F–I). MCM2, PCNA, Cyclin E1 and CDK2 were up-regulated in MTCH2-overexpressing cells and suppressed in MTCH2-silenced lines (J). Abbreviations: CCK-8, cell counting kit-8; PI, propidium iodide.
Article Snippet: The following antibodies were used:
Techniques: CCK-8 Assay, Cell Cycle Assay, Staining, Flow Cytometry, Cell Counting
Journal: Heliyon
Article Title: MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
doi: 10.1016/j.heliyon.2024.e28172
Figure Lengend Snippet: Xenografts in nude mice. Compared to the control group on the right side, overexpression of MTCH2 promoted tumor growth (A&C); silencing of MTCH2 suppressed tumor growth (B&D). Volumes of xenograft tumors were up and down regulated by MTCH2 over-expression and silencing, respectively (E&F). Weights were also up and down regulated by MTCH2 over-expression and silencing (G). (H&I) Protein levels of MTCH2 were confirmed by Western blot in over-expression and silenced models. (J) Immunohistochemical for biomarkers of cellular proliferation and cycle. Scale bar, 100 μm.
Article Snippet: The following antibodies were used:
Techniques: Control, Over Expression, Western Blot, Immunohistochemical staining
Journal: Heliyon
Article Title: MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
doi: 10.1016/j.heliyon.2024.e28172
Figure Lengend Snippet: MTCH2 activates the PI3K/Akt pathway: (A&B) Gene set enrichment analysis; (C&D) Phosphorylation of PI3K and Akt were enhanced with MTCH2 over-expression and inhibited with MTCH2 silencing.
Article Snippet: The following antibodies were used:
Techniques: Phospho-proteomics, Over Expression
Journal: Heliyon
Article Title: MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
doi: 10.1016/j.heliyon.2024.e28172
Figure Lengend Snippet: (A) CCK-8 assay indicates that the PI3K/Akt pathway activator IGF-1R rescued the anti-proliferative effect of MTCH2 silencing; the significance of differences between groups were evaluated with t -test. (B–E) Represented grapes of cell cycle analysis by PI staining and flow cytometry, (F) Schematic summarizing the connections between MTCH2, PI3K/Akt, IGF-1R and cell cycle regulation. Abbreviations: CCK-8, cell counting kit-8; PI, propidium iodide.
Article Snippet: The following antibodies were used:
Techniques: CCK-8 Assay, Cell Cycle Assay, Staining, Flow Cytometry, Cell Counting
Journal: ACS Applied Materials & Interfaces
Article Title: Dual-Targeted Biomimetic Nanoparticles for Enhanced Delivery of Polyphyllin B Synergistically Induce Ferroptosis and Immunogenic Cell Death in Gastric Cancer
doi: 10.1021/acsami.5c13198
Figure Lengend Snippet: Mechanisms of cell death. (A) Intracellular glutathione (GSH) concentration in SGC7901 cells after 24 h treatment with control, PB, HA@NPs-PB, and Ma/HA@NPs-PB. (B) Malondialdehyde (MDA) levels in SGC7901 cells following 24 h exposure to control, PB, HA@NPs-PB, and Ma/HA@NPs-PB. (C) Fe 2 + concentration in SGC7901 cells treated for 24 h with control, PB, HA@NPs-PB, and Ma/HA@NPs-PB. (D) GPX4 protein expression levels in SGC7901 cells after 24 h incubation with control, PB, HA@NPs-PB, and Ma/HA@NPs-PB. (E) The cell structure of PB, HA@NPs-PB and Ma/HA@NPs-PB treated for 24 h was observed by an electron microscope. The white arrow is the mitochondrial morphology of untreated cells, the yellow arrow is the mitochondrial morphology of treated cells, and the green arrow is the PB-induced autophagy vesicles. The data are expressed as the means ± SD ( n = 3). ns indicates no statistical significance. ** p < 0.01, *** p < 0.005, **** p < 0.001.
Article Snippet: Then, CDK4 (Cat. 83994-3-RR, Proteintech, China), CDK6 (Cat. 14052-1-AP, Proteintech, China), CyclinD1 (Cat. 26939-1-AP, Proteintech, China),
Techniques: Concentration Assay, Control, Expressing, Incubation, Microscopy
Journal: ACS Applied Materials & Interfaces
Article Title: Dual-Targeted Biomimetic Nanoparticles for Enhanced Delivery of Polyphyllin B Synergistically Induce Ferroptosis and Immunogenic Cell Death in Gastric Cancer
doi: 10.1021/acsami.5c13198
Figure Lengend Snippet: Antitumor growth effects and biosafety assessment of Ma/HA@NPs-PB on nude mice with HGC27 tumors. (A–C) Mice in the four groups were injected with DMSO, PB, HA@NPs-PB or Ma/HA@NPs-PB. The injection was repeated every 3 days. At the end of the experiment (day 21), the tumor morphology (A), tumor weight (B), and tumor volume (C) were determined. (D–I) Blood cells were measured by routine blood tests. (RBC, red blood cell; PLT, platelet; WBC, white blood cell; ALT, alanine aminotransferase; AST, glutamic oxalacetic transaminase; CREA, blood creatinine). (J) Histological staining of the heart, lungs, liver, spleen, and kidneys to assess the biosafety of the Ma/HA@NPs-PB drug delivery system. (K, L) Immunohistochemical staining for GPX4 with subsequent statistical analysis performed at the Ma/HA@NPs-PB drug delivery system. The data are expressed as the means ± SD ( n = 6). ns indicates no statistical significance. ** p < 0.01, *** p < 0.005, **** p < 0.001.
Article Snippet: Then, CDK4 (Cat. 83994-3-RR, Proteintech, China), CDK6 (Cat. 14052-1-AP, Proteintech, China), CyclinD1 (Cat. 26939-1-AP, Proteintech, China),
Techniques: Injection, Staining, Immunohistochemical staining
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 1 CBX3 expression in melanoma and its correlation with disease prognosis. (A) Upregulation of CBX3 in most cancers was confirmed in the GEPIA database. (B) CBX3 expression was significantly increased in melanoma compared to its level in normal tissues (102 primary tumor samples vs. 811 normal samples, p < 0.001). (C–E) Survival curves of patient groups differentiated by CBX3 expression level from TCGA, GSE133713, and GSE19234 datasets. (F) Representative image of CBX3/HP1γ staining (high/low expression) in tumor cell nuclei (left × 40, right × 400)
Article Snippet: The primary antibodies including
Techniques: Expressing, Staining
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 2 CBX3 expression in melanoma cell lines. (A) CBX3 expression in skin cancer cell lines (n = 62). (B, C) CBX3 mRNA expression in A375, Mewo, and A2058 cell lines was explored by qPCR and western blot. (D) Overexpression of CBX3 (oe) in a transfected A2058 cell line and knockout of CBX3 (sh) in transfected A375 and Mewo cell lines in comparison with CBX3 levels in the cells transfected with the control vector (nc) were verified by western blotting. All full-length blots are presented in Supplementary file 1. (n = 3, *p < 0.05, **p < 0.01)
Article Snippet: The primary antibodies including
Techniques: Expressing, Western Blot, Over Expression, Transfection, Knock-Out, Comparison, Control, Plasmid Preparation
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 3 CBX3 promotes proliferation and migration of melanoma cells. (A) Growth rates of melanoma cells with altered CBX3 expression were determined using the CCK8 assay. (B) Tumorigenicity of melanoma cells with altered CBX3 expression was measured using the colony assay. (C, D) Migration ability of melanoma cells with altered CBX3 expression was assessed using the wound healing and transwell assays. (n = 3, *p < 0.05, **p < 0.01)
Article Snippet: The primary antibodies including
Techniques: Migration, Expressing, CCK-8 Assay, Colony Assay
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 4 CBX3 promotes tumor formation in xenograft mice. (A, B) Growth of melanoma tumors in xenograft nude mice depending on CBX3 expression levels in implanted cells. (C) Relationship between CBX3 expression and tumor volume in vivo. (D) Relationship between CBX3 expression and tumor weight in vivo. (n = 3, *p < 0.05, **p < 0.01)
Article Snippet: The primary antibodies including
Techniques: Expressing, In Vivo
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 5 Regulation of cell cycle by CBX3. (A) Differential gene expression analysis based on the CBX3 expression level. (B, C) Functional enrichment of differentially expressed genes. (D) Analysis of cell cycle in cells with different levels of CBX3 expression was performed using flow cytometry
Article Snippet: The primary antibodies including
Techniques: Gene Expression, Expressing, Functional Assay, Flow Cytometry
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 6 Regulation of cell cycle by CBX3. (A) Expression levels of hallmark cell cycle proteins were determined using western blotting. (B) In vivo expression of cell cycle hallmark proteins. All full-length blots are presented in Supplementary file 1. (C–E) The 3D protein–protein interaction models created by HDOCK and pymol. Model 1 (C), model 2 (D), and model 4 (E) were selected based on the Docking Score, Confidence Score, and Ligand rmsd. All full-length blots are presented in Supplementary file 1. (n = 3, *p < 0.05, **p < 0.01)
Article Snippet: The primary antibodies including
Techniques: Expressing, Western Blot, In Vivo
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 7 Relationships between CBX3 expression and abundances of different immune cell populations in melanoma. (A) Single-cell sequencing (sc-seq) data from dataset GSE72056. (B) CBX3 expression in sc-seq data. (C) Directions of differentiation in sc-seq data determined by the pseudotime analysis. (D) Relationship between CBX3 expression coefficient and immune cell infiltration determined by the “CIBERSORT” package. (E) CBX3 expression levels in the cancer-immunity cycle
Article Snippet: The primary antibodies including
Techniques: Expressing, Sequencing
Journal: Stem cell research & therapy
Article Title: Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
doi: 10.1186/s13287-025-04179-8
Figure Lengend Snippet: Fig. 8 Hypothetical mechanism of cell cycle regulation by CBX3 in melanoma. CBX3 suppressed p21 expression, disrupted the inhibitory effect of p21 on the formation of the cell cycle protein kinase complex (cyclin D1–CDK6) and promoted the G1/S phase transition. Induced by mitogenic signals, cyclin D binds to CDK6 and promotes the phosphorylation of the retinoblastoma protein (RB), which separates the transcription factor E2F from the RB1– E2F1 complex, leading to the entry of the cell into the S phase and initiation of DNA replication
Article Snippet: The primary antibodies including
Techniques: Expressing, Sublimation, Phospho-proteomics